Vettrim-480 Oral

Composition: Contains per ml: Sulfadiazine ........................................................... 400 mg. Trimethoprim ........................................................... 80 mg. Solvents ad………………………………………......................... 1 ml.   Description: The combination of trimethoprim and sulfadiazine acts synergistic and usually bactericidal against many Gram-positive and Gramnegative bacteria like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. Both compounds affect bacterial purine synthesis in a different way, as a result of which a double blockade is accomplished.  Indications: Gastrointestinal and respiratory infections caused by trimethoprim and sulfadiazine sensitive micro-organisms, like E. coli, Haemophilus, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp. in calves, sheep, goats, poultry and swine.  Contra-Indications: Hypersensitivity to trimethoprim and/or sulfonamides. Administration to animals with a seriously impaired renal and/or liver function or with blood dyscrasias.  Side effects: After long-term treatment and high dosages crystalluria can occur. When symptoms of crystalluria occur (haematuria, kidney colic), treatment has to be stopped immediately and for example sodium carbonate (alkalinises) has to be administered for increasing urine solubility of sulfadiazine. Administration for a prolonged period also increases the risk for blood dyscrasias. Anaemia, leucopenia and thrombocytopenia.  Dosage: For oral administration: - Calves, goats and sheep : Twice daily 5 ml per 100 kg body weight for 4 - 7 days. - Poultry and swine: 1 litre per 1500 - 2500 litre drinking water for 4 7 days. Note: for pre-ruminant calves, lambs and kids only. Shake well before use.  Withdrawal times: - For meat: Calves, sheep, goats and swine : 8 days. Poultry: 5 days.  Packing: Bottle containing: 1 L